Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones.

Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.

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  • Zyloprim, Lopurin, Aloprim
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking allopurinol:

    More common:
    Ankle, knee, or great toe joint pain
    joint stiffness or swelling
    rash
    rash with flat lesions or small raised lesions on the skin
    Rare:
    Abdominal or stomach pain
    agitation
    ammonia-like breath odor
    anxiety
    bleeding gums
    blistering, peeling, or loosening of the skin
    blood in the urine or stools
    bloody nose
    bloody or black, tarry stools
    blue or pale skin
    bruising
    changes in skin color
    chest pain or discomfort
    chest pain, possibly moving to the left arm, neck, or shoulder
    chills
    clay-colored stools
    cloudy urine
    coma
    confusion
    constipation
    cough or hoarseness
    coughing up blood
    cracks in the skin
    dark urine
    decreased urine output
    depression
    diarrhea
    difficulty with breathing
    dizziness
    drowsiness
    dry mouth
    feeling faint, dizzy, or lightheaded
    feeling of warmth or heat
    fever
    fever with or without chills
    flushing or redness of the skin, especially on the face and neck
    general feeling of discomfort or illness
    general feeling of tiredness or weakness
    headache
    hostility
    incoherent speech
    increased urination
    irritability
    itching
    joint or muscle pain
    large, flat, blue or purplish patches in the skin
    lethargy
    light-colored stools
    loss of appetite
    loss of heat from the body
    lower back or side pain
    metallic taste
    muscle twitching
    muscle weakness
    nausea or vomiting
    pain, tenderness, or swelling of the foot or leg
    painful or difficult urination
    pinpoint red or purple spots on the skin
    rapid weight gain
    rash
    red, irritated eyes
    red, swollen skin
    redness, soreness, or itching skin
    right upper abdominal or stomach pain and fullness
    scaly skin
    seizures
    severe stomach pain
    shortness of breath
    slow or irregular heartbeat
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    sores, welting, or blisters
    stupor
    sweating
    swelling of the face, ankles, hands, or lower legs
    swollen or painful glands
    swollen, painful, or tender lymph glands in the neck, armpit, or groin
    thirst
    tightness in the chest
    unpleasant breath odor
    unusual bleeding or bruising
    unusual weight gain or loss
    vomiting of blood or material that looks like coffee grounds
    wheezing
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with allopurinol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Rare:
    Bad, unusual, or unpleasant (after) taste
    blindness
    blue-yellow color blindness
    blurred vision
    body aches or pain
    burning feeling in the chest or stomach
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    burning, dry, or itching eyes
    burning, numbness, tingling, or painful sensations
    change in taste
    change in vision
    congestion
    continuing ringing or buzzing or other unexplained noise in the ears
    decreased interest in sexual intercourse
    decreased vision
    difficulty with moving
    discharge or excessive tearing
    feeling of constant movement of self or surroundings
    hair loss or thinning of the hair
    hearing loss
    hives or welts
    impaired vision
    inability to have or keep an erection
    indigestion
    lack or loss of strength
    loss in sexual ability, desire, drive, or performance
    loss of appetite
    loss of memory
    multiple swollen and inflamed skin lesions
    muscle aching or cramping
    muscle pain or stiffness
    muscular pain, tenderness, wasting, or weakness
    noisy breathing
    problems with memory
    redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
    runny nose
    sensation of spinning
    sensitivity to light
    sleepiness or unusual drowsiness
    sleeplessness
    sneezing
    stomach upset
    stuffy nose
    sweating
    swelling of the breasts or breast soreness in both females and males
    swelling of the salivary glands
    swelling or inflammation of the mouth
    swollen joints
    tearing
    tender, swollen glands in the neck
    tenderness in the stomach area
    throbbing pain
    tightness in the chest
    trouble getting pregnant
    trouble with sleeping
    trouble with swallowing
    unable to sleep
    unsteadiness or awkwardness
    voice changes
    weakness in the arms, hands, legs, or feet
    weight loss
  • (oral tablet, intravenous powder for injection)