Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine and phenylephrine is a combination medicine used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

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  • Actifed Cold & Allergy, Allerest PE, ChlorTan D, Cold & Allergy Relief, Ed ChlorPed D, Sinus & Allergy PE, Sudafed PE Sinus & Allergy, Triaminic Cold & Allergy
  • Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

    Seek medical attention right away if any of these SEVERE side effects occur while taking chlorpheniramine / phenylephrine:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mood or mental changes; persistent trouble sleeping; restlessness; seizures; severe dizziness, drowsiness, lightheadedness, or headache; tremor.
  • (oral tablet, oral tablet, chewable, oral suspension, oral liquid, oral elixir, oral capsule, extended release, oral suspension, extended release, oral tablet, extended release, oral syrup, oral drops)