Acetaminophen is a pain reliever and fever reducer.

Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing.

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, dextromethorphan, doxylamine, and phenylephrine is a combination medicine used to treat headache, fever, body aches, cough, runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.

This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

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  • Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.

    Seek medical attention right away if any of these SEVERE side effects occur while taking acetaminophen / dextromethorphan / doxylamine / phenylephrine:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mental or mood changes; pale stools; seizures; severe nervousness, drowsiness, or trouble sleeping; severe or persistent dizziness, lightheadedness, or headache; severe or persistent stomach pain, nausea, or vomiting; tremor; unusual fatigue; vision changes; yellowing of the skin or eyes.
  • (oral tablet, effervescent, oral liquid, oral tablet, oral capsule)