Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.
Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Aspirin, chlorpheniramine, and phenylephrine is a combination medicine used to treat fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.
Alka-Seltzer Plus Cold Formula
Constipation; diarrhea; dizziness; drowsiness; dry mouth; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.
Seek medical attention right away if any of these SEVERE side effects occur while taking aspirin / chlorpheniramine / phenylephrine:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; blurred vision or other vision changes; confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; heartburn; mood or mental changes; persistent trouble sleeping; restlessness; ringing in the ears or hearing loss; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; severe or persistent stomach pain, nausea, or vomiting; tremor; unusual bruising or bleeding; vomit that is bloody or looks like coffee grounds.
(oral tablet, effervescent)