Methyldopa and hydrochlorothiazide combination is used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Methyldopa works by controlling nerve impulses along certain nerve pathways. As a result, it relaxes blood vessels so that blood passes through them more easily. Hydrochlorothiazide helps reduce the amount of water in the body by increasing the flow of urine. These actions help to lower blood pressure.

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  • methyldopa and hydrochlorothiazide
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking hydrochlorothiazide / methyldopa:

    Rare:
    Unexplained fever shortly after starting to take this medicine
    Severity: Moderate
    If any of the following side effects occur while taking hydrochlorothiazide / methyldopa, check with your doctor or nurse as soon as possible:

    Signs and symptoms of too much potassium loss
    Dry mouth
    increased thirst
    irregular heartbeats
    muscle cramps or pain
    nausea or vomiting
    unusual tiredness or weakness
    weak pulse
    Less common:
    Mental depression or anxiety
    nightmares or unusually vivid dreams
    Rare:
    Cough or hoarseness
    dark or amber urine
    diarrhea or stomach cramps (severe or continuing)
    fever, chills, troubled breathing, and fast heartbeat
    general feeling of discomfort or illness or weakness
    joint pain
    lower back or side pain
    painful or difficult urination
    pale stools
    skin rash, hives, or itching
    stomach pain (severe) with nausea and vomiting
    tiredness or weakness after having taken this medicine for several weeks (continuing)
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with hydrochlorothiazide / methyldopa may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Dizziness or light-headedness when getting up from a lying or sitting position
    drowsiness
    dryness of mouth
    headache
    Less common:
    Decreased sexual ability or interest in sex
    diarrhea
    increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin or severe sunburn after exposure to sunlight)
    loss of appetite
    numbness, tingling, pain, or weakness in hands or feet
    slow heartbeat
    stuffy nose
    swelling of breasts or unusual milk production
  • (methyldopa and hydrochlorothiazide) Tablets