Aflibercept is made from a human antibody fragment. It works by keeping new blood vessels from forming under the retina (a sensory membrane that lines the inside of the eye). In people with a certain type of eye disease, new blood vessels grow under the retina where they leak blood and fluid. This is known as the “wet form” of macular degeneration.

Aflibercept ophthalmic (for the eyes) is used to treat wet age-related macular degeneration. Aflibercept is also used to treat swelling in the retina caused by a blockage in the blood vessels.

Aflibercept ophthalmic is also used to treat diabetic retinopathy, an eye disorder in diabetics that can lead to a buildup of fluid in the retina and cause blindness.

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  • Eylea
  • More common:
    bloody eye
    blurred vision
    eye or eyelid redness
    eye pain
    seeing flashes, sparks of light, or a veil or curtain
    seeing floating spots before the eyes
    vision changes
    Less common:
    Bleeding or pain at the injection site
    swelling of the eyelid
    Fast heartbeat
    hives, itching, rash, or skin redness
    joint pain, stiffness, or swelling
    swelling of the face, lips, hands, or feet
    troubled breathing or swallowing
    Incidence not known:
    Pain in the chest, groin, or legs, especially the calves
    severe, sudden headache
    slurred speech
    sudden loss of coordination
    sudden, severe weakness or numbness in the arm or leg
    sudden, unexplained shortness of breath
    Severity: Minor
    Some of the side effects that can occur with aflibercept ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common:
    Feeling like something is in the eye
    watery eyes
  • (intraocular solution)