Everolimus is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

The Afinitor brand of everolimus is used to treat certain types of kidney cancer, breast cancer, or brain tumor. Afinitor is also used to treat certain types of advanced or progressive tumors of the stomach, intestines, or pancreas. Afinitor is usually given after other treatments have been tried without success.

Afinitor is also used to treat non-cancerous (benign) tumors of the kidney in people with a certain genetic condition called tuberous sclerosis complex.

This medication guide provides information about the Afinitor brand of everolimus. Zortress is another brand of everolimus used to prevent organ rejection after a kidney transplant.

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  • Afinitor, Afinitor Disperz
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking everolimus:

    More common:
    Bloating or swelling of the face, arms, hands, lower legs, or feet
    bloody nose
    chest pain or tightness
    cough or hoarseness
    decreased weight
    diarrhea
    difficult or labored breathing
    difficulty with swallowing
    fever or chills
    general feeling of discomfort or illness
    lower back or side pain
    painful or difficult urination
    rapid weight gain
    sores, ulcers, or white spots on the lips, tongue, or inside the mouth
    tingling of the hands or feet
    Less common:
    Bleeding gums
    bloody urine
    blurred vision
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    coughing up blood
    extreme fatigue
    fast, pounding, or irregular heartbeat or pulse
    increased thirst or urination
    irregular breathing
    loss of appetite
    nausea or vomiting
    nervousness
    nosebleeds
    prolonged bleeding from cuts
    red or black, tarry stools
    red or dark brown urine
    slow heartbeat
    stomachache
    sweating
    unusual tiredness or weakness
    Incidence not known:
    Agitation
    confusion
    depression
    dizziness
    hostility or irritability
    lethargy
    muscle twitching
    seizures
    stupor
    Severity: Minor
    Some of the side effects that can occur with everolimus may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Abdominal or stomach pain
    change in taste
    dry skin
    itching skin
    lack or loss of strength
    loss of taste
    pain in the arms or legs
    rash
    unable to sleep
    Less common:
    Back pain
    blistering, peeling, redness, or swelling of the palms, hands, or bottoms of the feet
    bumps on the skin
    burning, dry, or itching eyes
    discoloration of the fingernails or toenails
    flushing or redness of the skin
    full feeling
    jaw pain
    numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
    passing gas
    redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
    sleepiness or unusual drowsiness
  • (oral tablet, oral tablet, dispersible)