Antihemophilic factor is a naturally occurring protein in the blood that helps blood to clot. A lack of antihemophilic factor VIII is the cause of hemophilia A.

Recombinant antihemophilic factor works by temporarily raising levels of factor VIII in the blood to aid in clotting.

Recombinant antihemophilic factor is used to treat or prevent bleeding episodes in adults and children with hemophilia A. It is also used to control bleeding related to surgery or dentistry in a person with hemophilia, and to prevent joint damage in people age 16 or older with severe hemophilia A and no prior joint damage.

Recombinant antihemophilic factor is not for use in people with von Willebrand disease.

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  • Advate, Adynovate, Eloctate with Fc Fusion Protein, Helixate FS, Kogenate FS, Novoeight, Nuwiq, Recombinate, Xyntha
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking antihemophilic factor:

    More common:
    Fever
    Less common or rare:
    Changes in facial skin color
    chills
    fast or irregular breathing
    nausea
    puffiness or swelling of the eyelids or around the eyes
    sensation of burning, warmth, heat, numbness, tightness, or tingling
    skin rash, hives, or itching
    tightness in the chest
    troubled breathing
    unusual tiredness or weakness
    Incidence not known:
    Bluish color of the fingernails, lips, skin, palms, or nail beds
    blurred vision
    chest pain or discomfort
    confusion
    cough
    deep or fast breathing with dizziness
    difficult or labored breathing
    difficulty with swallowing
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fast, pounding, or irregular heartbeat or pulse
    noisy breathing
    numbness of the feet, hands, and around the mouth
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    slow or irregular heartbeat
    sweating
    swelling of the face, throat, or tongue
    unusual tiredness or weakness
    Severity: Minor
    Some of the side effects that can occur with antihemophilic factor may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Headache
    Less common:
    Burning, stinging, or swelling at the place of injection
    diarrhea
    dizziness or lightheadedness
    dry mouth or bad taste in the mouth
    lack or loss of strength
    nosebleed
    redness of the face
    vomiting
    Rare:
    Change in taste
    loss of taste
    Incidence not known:
    Abdominal or stomach pain
    feeling of warmth
    increased sweating
    irritability
    muscle or bone pain
    redness of the eye
    redness of the face, neck, arms, and occasionally, upper chest
    redness of the skin
    trouble seeing
  • (intravenous powder for injection, intravenous kit)