Fluticasone and salmeterol is a combination of two medicines that are used to help control the symptoms of asthma and improve breathing. It is used when a patient’s asthma has not been controlled sufficiently on other asthma medicines, or when a patient’s condition is so severe that more than one medicine is needed every day. This medicine will not relieve an asthma attack that has already started.

This medicine is also used to treat air flow blockage and reduce the worsening of chronic obstructive pulmonary disease (COPD). This includes chronic bronchitis and emphysema.

Inhaled fluticasone belongs to the family of medicines known as corticosteroids or steroids (cortisone-like medicines). It works by preventing certain cells in the lungs and breathing passages from releasing substances that cause asthma symptoms.

Inhaled salmeterol is a long-acting bronchodilator. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. It relieves cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine must be used with a short-acting medicine (e.g. albuterol) for an asthma attack or asthma symptoms that need attention right away.

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  • fluticasone and salmeterol
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking fluticasone / salmeterol:

    More common:
    Black, tarry stools
    blurred vision
    burning, tingling, numbness, or pain in the hands, arms, feet, or legs
    decreased vision
    difficulty with breathing or swallowing
    eye pain
    fast heartbeat
    hives or welts
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    nausea or vomiting
    noisy breathing
    painful or difficult urination
    sensation of pins and needles
    shortness of breath
    skin itching, rash, or redness
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    stabbing pain in the arms or legs
    swelling of the face, throat, or tongue
    swollen glands
    unusual bleeding or bruising
    Incidence not known:
    Abdominal or stomach pain
    darkening of the skin
    decrease in height
    difficulty with moving
    facial hair growth in females
    fast, slow, pounding, or irregular heartbeat or pulse
    flushed, dry skin
    fruit-like breath odor
    full or round face, neck, or trunk
    heavy bleeding
    increased hunger
    increased thirst or urination
    large, flat, blue, or purplish patches in the skin
    loss of sexual desire or ability
    menstrual irregularities
    mental depression
    muscle pain or stiffness
    muscle wasting
    pain in the back, ribs, arms, or legs
    pain in the joints
    troubled breathing
    unexplained weight loss
    unusual tiredness or weakness
    weight gain
    If any of the following symptoms of overdose occur while taking fluticasone / salmeterol, get emergency help immediately:

    Symptoms of overdose:
    Chest pain or tightness
    convulsions (seizures)
    decreased urine output
    dry mouth
    faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    general feeling of discomfort or illness
    high blood pressure
    loss of appetite
    mood changes
    numbness or tingling in the hands, feet, or lips
    sudden sweating
    trouble with sleeping
    Severity: Minor
    Some of the side effects that can occur with fluticasone / salmeterol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Body aches or pain
    dryness of the throat
    high-pitched noise when breathing
    runny nose
    trouble with swallowing
    voice changes
    Less common:
    Cough-producing mucus
    flu-like symptoms
    irritation or inflammation of the eye
    muscle pain
    pain or tenderness around the eyes and cheekbones
    sleep disorders
    stuffy nose
    white patches in the mouth or throat or on the tongue
  • (fluticasone propionate and salmeterol xinafoate) aerosol, metered