Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection.

Hydrocortisone is a topical (for the skin) steroid. It reduces the actions of chemicals in the body that cause inflammation.

The combination of acyclovir and hydrocortisone topical (for the skin) is used to treat cold sores in people who are at least 12 years old.

This medication will not cure or prevent cold sores caused by herpes, but it can lessen the symptoms of the infection.

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  • Xerese
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking acyclovir / hydrocortisone topical:

    Rare:
    Burning, itching, redness, rash, swelling, soreness, or tingling at the application site
    change in skin color at the application site
    dryness or flaking of the skin
    flushing or redness of the skin
    unusually warm skin
    Incidence not known:
    Blistering, burning, or crusting of the skin
    itching, scaling, severe redness, soreness, or swelling of the skin
  • (topical cream)