Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Norethindrone is a form of progesterone, a female hormone important for regulating ovulation and menstruation.

Estradiol and norethindrone is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes (itching, burning, dryness), and to prevent osteoporosis (bone loss) in menopausal women.

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  • Activella, Ena, Mimvey
  • More common:
    Body aches or pain
    chills or fever
    cold or flu-like symptoms
    difficulty breathing
    headache
    itching of the vagina or genital area
    nonmenstrual vaginal bleeding
    pain during sexual intercourse
    thick, white vaginal discharge with no odor or with a mild odor
    unusual tiredness or weakness
    Incidence not known:
    Abdominal or stomach pain
    blistering, peeling, or loosening of the skin
    change in vaginal discharge
    chest pain, discomfort, or tightness in chest
    clay-colored stools
    clear or bloody discharge from the nipple
    confusion
    dark urine
    difficulty speaking
    difficulty swallowing
    dizziness or lightheadedness
    double vision
    fainting
    fast heartbeat
    inability to move the arms, legs, or facial muscles
    inability to speak
    joint or muscle pain
    loss of appetite
    lump in the breast or under the arm
    nausea and vomiting
    noisy breathing
    pain in the ankles or knees
    pain or discomfort in the arms, jaw, back, or neck
    pain or feeling of pressure in the pelvis
    pain, redness, or swelling in the arm or leg
    painful, red lumps under the skin, mostly on the legs
    pains in the stomach, side, or abdomen, possibly radiating to the back
    problems with memory or speech
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    red, irritated eyes
    redness or swelling of the breast
    skin rash, hives, or itching
    sores, ulcers, or white spots in the mouth or on the lips
    sudden shortness of breath or troubled breathing
    sweating
    trouble recognizing objects
    trouble thinking and planning
    trouble walking
    Severity: Minor
    Some of the side effects that can occur with estradiol / norethindrone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Back pain
    breast pain
    cramps
    crying
    euphoria
    mental depression
    paranoia
    quick to react or overreact emotionally
    rapidly changing moods
    trouble sleeping
    weakness
    weight gain
    Incidence not known:
    Changes in appetite
    changes in sexual ability, desire, drive, or performance
    excess air or gas in the stomach or intestines
    increased hair growth, especially on the face
    patchy brown or dark brown discoloration of the skin
    trouble wearing contact lenses
  • (estradiol and norethindrone acetate) tablet, film coated