Treating moderate to severe rheumatoid arthritis (RA) in certain patients. It is also used to treat juvenile idiopathic arthritis in children 2 years old and older. It may be used alone or in combination with other medicine. It may also be used for other conditions as determined by your doctor.

Actemra Intravenous is an interleukin-6 (IL-6) receptor blocker. It works by blocking a substance (IL-6) in the body that contributes to inflammation.

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  • Actemra
  • More common:
    Abdominal or stomach pain
    black, tarry stools
    bloody or cloudy urine
    blurred vision
    body aches or pain
    chest pain
    cough producing mucus
    difficult, burning, or painful urination
    difficulty breathing
    difficulty swallowing
    ear congestion
    fast heartbeat
    feeling of warmth
    fever or chills
    frequent urge to urinate
    loss of appetite
    loss of consciousness
    loss of voice
    lower back or side pain
    nasal congestion
    pain or tenderness around the eyes and cheekbones
    painful blisters on the trunk of the body
    pale skin
    pounding in the ears
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    redness of the face, neck, arms, and occasionally, upper chest
    shortness of breath or troubled breathing
    skin rash
    slow or fast heartbeat
    sore throat
    stuffy or runny nose
    sudden sweating
    tightness of the chest or wheezing
    ulcers, sores, or white spots in the mouth
    unusual bleeding or bruising
    unusual tiredness or weakness
    Less common:
    Bladder pain
    blurred vision
    burning feeling in the chest or stomach
    dark urine
    decrease in height
    difficulty moving
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fast, irregular, pounding, or racing heartbeat or pulse
    feeling hot
    frequent urge to urinate
    general feeling of discomfort or illness
    itching, pain, redness, swelling, tenderness, or warmth on the skin at the injection site
    joint pain
    light-colored stools
    muscle aches and pains
    muscle cramps or stiffness
    pain in the back, ribs, arms, or legs
    pain in the groin or genitals
    pale skin
    severe stomach pain
    sharp back pain just below the ribs
    stomach upset
    swollen joints
    swollen, painful, or tender lymph glands in the face, neck, armpit, or groin
    tenderness in the stomach area
    trouble with sleeping
    troubled breathing with exertion
    unexplained runny nose or sneezing
    upper right abdominal or stomach pain
    yellow eyes and skin
    Acid or sour stomach
    changes in skin color
    coughing or spitting up blood
    gaseous abdominal or stomach pain
    neck pain
    night sweats
    noisy breathing
    pain, swelling, or redness in the joints
    rapid, shallow breathing
    recurrent fever
    red, tender, or oozing skin at incision
    stomach bloating, burning, cramping, or pain
    sudden high fever or low-grade fever for months
    swelling of the foot or leg
    swollen lymph nodes
    weight loss
    Incidence not known:
    Dilated neck veins
    extreme fatigue
    severe abdominal or stomach pain, cramping, or burning
    swelling of the face, fingers, feet, or lower legs
    vomiting of material that looks like coffee grounds, severe and continuing
    weight gain
    Severity: Minor
    Some of the side effects that can occur with tocilizumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Burning, dry, or itching eyes
    discharge, excessive tearing
    redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
    skin rash, encrusted, scaly and oozing
    swelling or inflammation of the mouth
    warmth on the skin
    Less common:
    Abnormal or decreased touch sensation
    accumulation of pus
    back pain
    bleeding gums
    blemishes on the skin
    bloody eye
    chapped, red, or swollen lips
    feeling of constant movement of self or surroundings
    hives or welts
    irritation in the mouth
    loose teeth
    persistent breath odor or bad taste in your mouth
    redness and swelling of the gums
    redness of the eye
    redness of the skin
    redness or swelling in the ear
    scaling, redness, burning, pain, or other signs of inflammation of the lips
    sensation of spinning
    sore mouth or tongue
    sores on the skin
    stomach soreness or discomfort
    swollen, red, or tender area of infection
    unable to sleep
    white patches in the mouth or on the tongue
    Bleeding after defecation
    bloody nose
    burning, numbness, tingling, or painful sensations
    change in hearing
    continuing ringing or buzzing or other unexplained noise in the ears
    coughing or spitting up blood
    decreased vision or other changes in vision
    dry mouth
    ear drainage
    flushed, dry skin
    fruit-like breath odor
    hearing loss
    increased hunger
    increased thirst
    increased urination
    itching ears
    loss of consciousness
    redness, swelling, or soreness of the tongue
    uncomfortable swelling around the anus
    unexplained weight loss
    unsteadiness or awkwardness
    weakness in the arms, hands, legs, or feet
  • (tocilizumab) injection, solution, concentrate