Zafirlukast is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.

Zafirlukast is used for chronic treatment of asthma, and to prevent asthma attacks in adults and children as young as 5 years old.

Do not give this medicine to a child younger than 5 years without a doctor’s advice.

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  • Accolate
  • Less common:
    Cough or hoarseness
    fever or chills
    lower back or side pain
    pain
    painful or difficult urination
    Rare:
    Abdominal or stomach pain
    clay-colored stools
    dark urine
    diarrhea
    dizziness
    headache
    itching
    loss of appetite
    nausea
    rash
    unpleasant breath odor
    unusual tiredness or weakness
    vomiting of blood
    yellow eyes or skin
    Incidence not known:
    Attack, assault, or force
    attempts at killing oneself
    discouragement
    dry mouth
    fear or nervousness
    feeling sad or empty
    fever with or without chills
    general feeling of tiredness or weakness
    hyperventilation
    irregular heartbeats
    irritability
    lack of appetite
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    loss of interest or pleasure
    restlessness
    seeing, hearing, or feeling things that are not there
    shakiness in the legs, arms, hands, or feet
    shortness of breath
    sleeplessness
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    tiredness
    trembling or shaking of the hands or feet
    trouble with concentrating
    trouble with sleeping
    unable to sleep
    unusual bleeding or bruising
    Severity: Minor
    Some of the side effects that can occur with zafirlukast may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common:
    Acid or sour stomach
    back pain
    belching
    difficulty with moving
    heartburn
    indigestion
    joint pain
    lack or loss of strength
    muscle aching or cramping
    muscle pains or stiffness
    stomach discomfort or upset
    swollen joints
    vomiting
    Incidence not known:
    Hives or welts
    redness of the skin
  • (zafirlukast) tablet, coated