Emtricitabine and tenofovir are antiviral drugs that work by preventing HIV (human immunodeficiency virus) cells from multiplying in the body.

Emtricitabine and tenofovir is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS, but it can be used to treat HIV in adults and children who are at least 12 years old and weigh at least 17 kilograms (37 pounds).

The Truvada brand of this medicine may be used together with safer-sex practices to reduce the risk of becoming infected with HIV. You must be HIV-negative and an adult to use Truvada for this purpose. Truvada may not provide protection from disease in every person.

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  • AccessPak for HIV PEP Basic, Descovy, Truvada
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking emtricitabine / tenofovir:

    Less common:
    Blisters under the skin
    rash with flat lesions or small raised lesions on the skin
    redness of the skin
    skin rash, itching skin, hives or welts
    spots on your skin resembling a blister or pimple
    Rare:
    Blindness or vision changes
    burning of the face or mouth
    burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings in the hands, arms, feet, or legs
    chest pain
    clumsiness or unsteadiness
    sensation of pins and needles
    sneezing
    sore throat
    stabbing pain
    weakness in the hands or feet
    Incidence not known:
    Abdominal or stomach discomfort
    agitation
    bloating
    bloody or cloudy urine
    bone pain
    chills
    coma
    confusion
    constipation
    convulsions or seizures
    cough
    darkened urine
    decreased appetite
    decreased frequency or amount of urine
    depression
    diarrhea
    difficult or labored breathing
    difficult or painful urination
    difficulty with swallowing
    dizziness
    fast heartbeat
    fast, shallow breathing
    fever
    general feeling of discomfort
    headache
    hostility
    increase in the amount of urine
    increased blood pressure
    increased thirst
    indigestion
    irritability
    lethargy
    loss of appetite
    lower back or side pain
    muscle pain or cramping
    muscle twitching
    nausea
    pains in the stomach, side, or abdomen, possibly radiating to the back
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rapid weight gain
    sleepiness
    stupor
    sudden decrease in the amount of urine
    swelling of the face, fingers, hands, lower legs, or ankles
    tightness in the chest
    trouble breathing
    unusual tiredness or weakness
    vomiting
    weight gain
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with emtricitabine / tenofovir may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common:
    Lack or loss of strength
    passing of gas
    weight loss
    Rare:
    Acid or sour stomach
    back pain
    belching
    difficulty with moving
    discouragement
    feeling sad or empty
    heartburn
    increased cough
    joint pain
    loss of interest or pleasure
    muscle aching or cramping
    muscle pain or stiffness
    pain
    runny nose
    stomach upset
    stuffy nose
    sweating
    swollen joints
    tiredness
    trouble concentrating
    trouble sleeping
  • (oral tablet, oral kit)